ORS Meniscus Section: Meniscus Semi-Circular Newsletter
September 2019

 

ORS Meniscus Section Member Spotlight: Norimasa Nakamura, MD, PhD, Osaka Health Science University

Current Title and Department
Professor, Institute for Medical Science in Sports

Current Employer
Osaka Health Science University

Undergraduate Degree, University
MD, Osaka University

Graduate Degree, University
PhD, Osaka University

Post-doctoral Position
Fellow, University of Calgary

Past Employers
Osaka University

Who have been your mentors?
Yasufumi Kaneda, MD, PhD, Cyril B. Frank, MD

What are your specific research areas and expertise, particularly related to the meniscus?  
Stem cell therapy, biomaterials

What are you currently working on?
Stem cell therapy in Cartilage Repair and Osteoarthritis; Bio-active membrane to augment incurable meniscal repair

What has been the biggest challenge for you lately in your research?
Clinical application of allogenic stem cell-based cartilage repair. Phase III clinical trial

What project(s) are you looking forward to in the near future?
Clinical application of extra-vesicles in osteoarthritis

What advice would you give investigators who are just starting out in the field?
(1) Extensive review on recent papers in related areas of your expertise and (2) Careful observation of every data in your experiments

When you're not in the lab, what do you like to do for fun?
Playing golf with nice friends

What was the last book you read for fun and would you recommend it?
Killing Commendatore by Haruki Murakami

What is the most unusual/unexpected item sitting on your desk right now?
A letter from my old friend (so nice!)


ORS Meniscus Section Member Spotlight: Sonia Bansal, BS, University of Pennsylvania

Current Title and Department
Graduate Student, Departments of Bioengineering and Orthopedic Surgery, University of Pennsylvania

Current Employer
Mauck Lab, McKay Orthopedics Lab, University of Pennsylvania

Undergraduate Degree, University
Columbia University, B.S. in Biomedical Engineering

Graduate Degree, University
University of Pennsylvania, PhD in Bioengineering (expected 2020)

Post-doctoral Position
TBD!

Past Employers
Cellular Engineering Lab at Columbia University, Janssen Pharmaceuticals (summer internship)

Who have been your mentors?
Dr. Rob Mauck, Dr. Clark Hung, Dr. Brendan Roach, Dr. Sylvia Qu

What are your specific research areas and expertise, particularly related to the meniscus?
Surgical animal models and post-natal maturation

What are you currently working on?
A large animal model of meniscus injury

What has been the biggest challenge for you lately in your research?
 I’m planning to start some experiments that I’ve never done before, so I’ve been reading a lot and trying to just get started on it.

What project(s) are you looking forward to in the near future?
We have a long time point coming up for our large animal model of meniscus injury and I’m excited to see how that shakes out.

What advice would you give investigators who are just starting out in the field?
Don’t be afraid to ask questions or for help with something. Everyone starts somewhere, and chances are, they are happy to help you along the way.

When you're not in the lab, what do you like to do for fun?
I enjoy social latin dancing and have recently picked up aerial acrobatic yoga.

What was the last book you read for fun and would you recommend it?
"The Opposite of Loneliness" by Marina Keegan. I very much recommend it! I couldn't put it down and ended up reading it in 3 days.

What is the most unusual/unexpected item sitting on your desk right now?
Hard to pick between a bag of confetti labeled "A tiny celebration" and an instax camera.

Follow me on Twitter! @soniab742

Latest Meniscus Related Publications by ORS Meniscus Section Members 

  • Nakagawa K, Otsuki S, Murakami T, Okamoto Y, Okuno N, Wakama H, Sezaki S, Ikeda K, Okayoshi T, Neo M. Histological Analysis of the Wrapping Treatment for Meniscal Horizontal Tears in Rabbits. Cartilage. 2019 Aug 30:1947603519870838. doi: 10.1177/1947603519870838.
  • Allen KD, Chan KM, Yarmola EG, Shah YY, Partain BD. The Effects of Age on the Severity of Joint Damage and Intra-Articular Inflammation Following a Simulated Medial Meniscus Injury in 3, 6, and 9 Month Old Male Rats. Connect Tissue Res. 2019 Aug 23:1-13.
  • Hagmeijer MH, Vonk LA, Fenu M, van Keep YW, Krych AJ, Saris DB. Meniscus Regeneration Combining Meniscus and Mesenchymal Stromal Cells in a Degradable Meniscus Implant: An In Vitro Study. Eur Cell Mater. 2019 Aug 12;38:51-62.
  • Bernard CD, McGauvran AM, Desai VS, Frick MA, Tiegs-Heiden C, Camp CLA, Krych AJ, Collins MS. Understanding the Implications of the Meniscal Ossicle: Patient Presentation, Treatment, and Outcomes. J Knee Surg. 2019 Aug 7. doi: 10.1055/s-0039-1693724.
  • Nakagawa Y, Fortier LA, Mao JJ, Lee CH, Goodale MB, Koff MF, Uppstrom TJ, Croen B, Wada S, Carballo CB, Potter HG, Rodeo SA. Long-term Evaluation of Meniscal Tissue Formation in 3-Dimensional-Printed Scaffolds with Sequential Release of Connective Tissue Growth Factor and TGF-β3 in an Ovine Model. Am J Sports Med. 2019 Aug 6:363546519865513.
  • Sabbag OD, Hevesi M, Sanders TL, Camp CL, Dahm DL, Levy BA, Stuart MJ, Krych AJ. High Rate of Recurrent Meniscal Tear and Lateral Compartment Osteoarthritis in Patients Treated for Symptomatic Lateral Discoid Meniscus: A Population-Based Study. Orthop J Sports Med. 2019 Jul 19;7(7):2325967119856284.
  • Ishii Y, Ishikawa M, Kurumadani H, Hayashi S, Nakamae A, Nakasa T, Sumida Y, Tsuyuguchi Y, Kanemitsu M, Deie M, Adachi N, Sunagawa T. Increase in Medial Meniscal Extrusion in the Weight-Bearing Position Observed on Ultrasonography Correlates with Lateral Thrust in Early-Stage Knee Osteoarthritis. J Orthop Sci. 2019 Jul 23. pii: S0949-2658(19)30205-2.
  • Huebner P, Warren PB, Chester D, Spang JT, Brown AC, Fisher MB, Shirwaiker RA. Mechanical Properties of Tissue Formed In Vivo are Affected by 3D-Bioplotted Scaffold Microarchitecture and Correlate with ECM Collagen Fiber Alignment. Connect Tissue Res. 2019 Jul 26:1-15.
  • Bahcecioglu G, Bilgen B, Hasirci N, Hasirci V. Anatomical Meniscus Construct with Zone Specific Biochemical Composition and Structural Organization. Biomaterials. 2019 Oct;218:119361.
  • Leafblad ND, Leland DP, Camp CL, Stuart MJ, Krych AJ. Arthroscopic Repair of Double Radial Tears of the Lateral Meniscus. Arthrosc Tech. 2019 May 6;8(6):e541-e547.
  • Krych AJ, Bernard CD, Leland DP, Camp CL, Johnson AC, Finnoff JT, Stuart MJ. Isolated Meniscus Extrusion Associated with Meniscotibial Ligament Abnormality. Knee Surg Sports Traumatol Arthrosc. 2019 Jul 22. doi: 10.1007/s00167-019-05612-1.
  • Brial C, McCarthy M, Adebayo O, Wang H, Chen T, Warren R, Maher S. Lateral Meniscal Graft Transplantation: Effect of Fixation Method on Joint Contact Mechanics During Simulated Gait. Am J Sports Med. 2019 Aug;47(10):2437-2443.
  • Sekiya I, Koga H, Otabe K, Nakagawa Y, Katano H, Ozeki N, Mizuno M, Horie M, Kohno Y, Katagiri K, Watanabe N, Muneta T. Additional Use of Synovial Mesenchymal Stem Cell Transplantation Following Surgical Repair of a Complex Degenerative Tear of the Medial Meniscus of the Knee: A Case Report. Cell Transplant. 2019 Jul 17:963689719863793.
  • Boys AJ, Kunitake JAMR, Henak CR, Cohen I, Estroff LA, Bonassar LJ. Understanding the Stiff-to-Compliant Transition of the Meniscal Attachments by Spatial Correlation of Composition, Structure, and Mechanics. ACS Appl Mater Interfaces. 2019 Jul 31;11(30):26559-26570.
  • Novaretti JV, Lian J, Sheean AJ, Chan CK, Wang JH, Cohen M, Debski RE, Musahl V. Lateral Meniscal Allograft Transplantation with Bone Block and Suture-Only Techniques Partially Restores Knee Kinematics and Forces. Am J Sports Med. 2019 Aug;47(10):2427-2436.
  • Ruprecht JC, Waanders TD, Rowland CR, Nishimuta JF, Glass KA, Stencel J, DeFrate LE, Guilak F, Weinberg JB, McNulty AL. Meniscus-Derived Matrix Scaffolds Promote the Integrative Repair of Meniscal Defects. Sci Rep. 2019 Jun 18;9(1):8719.
  • Balazs GC, Greditzer HG 4th, Wang D, Marom N, Potter HG, Marx RG, Rodeo SA, Williams RJ 3rd. Ramp Lesions of the Medial Meniscus in Patients Undergoing Primary and Revision ACL Reconstruction: Prevalence and Risk Factors. Orthop J Sports Med. 2019 May 15;7(5):2325967119843509.
  • Tu J, Zhang P, Ji Z, Henneicke H, Li J, Kim S, Swarbrick MM, Wu Y, Little CB, Seibel MJ, Zhou H. Disruption of Glucocorticoid Signalling in Osteoblasts Attenuates Age-Related Surgically Induced Osteoarthritis. Osteoarthritis Cartilage. 2019 Jun 5. pii: S1063-4584(19)31066-0. doi: 10.1016/j.joca.2019.04.019.
  • Otsuki S, Nakagawa K, Murakami T, Sezaki S, Sato H, Suzuki M, Okuno N, Wakama H, Kaihatsu K, Neo M. Evaluation of Meniscal Regeneration in a Mini Pig Model Treated with a Novel Polyglycolic Acid Meniscal Scaffold. Am J Sports Med. 2019 Jul;47(8):1804-1815.
  • Wang D, Marom N, Coxe FR, Kalia V, Burge AJ, Jones KJ, Rodeo SA, Williams RJ 3rd. Preoperative Grades of Osteoarthritis and Meniscus Volume Correlate with Clinical Outcomes of Osteochondral Graft Treatment for Cartilage Defects in the Knee. Cartilage. 2019 Jun 4:1947603519852402. doi: 10.1177/1947603519852402.
  • Liang Y, Szojka ARA, Idrees E, Kunze M, Mulet-Sierra A, Adesida AB. Re-Differentiation of Human Meniscus Fibrochondrocytes Differs in Three-Dimensional Cell Aggregates and Decellularized Human Meniscus Matrix Scaffolds. Ann Biomed Eng. 2019 May 30. doi: 10.1007/s10439-019-02272-7.
  • Hagmeijer MH, Hevesi M, Desai VS, Sanders TL, Camp CL, Hewett TE, Stuart MJ, Saris DBF, Krych AJ. Secondary Meniscal Tears in Patients with Anterior Cruciate Ligament Injury: Relationship Among Operative Management, Osteoarthritis, and Arthroplasty at 18-Year Mean Follow-up. Am J Sports Med. 2019 Jun;47(7):1583-1590.
  • Morgan OJ, Hillstrom HJ, Ranawat A, Fragomen AT, Rozbruch SR, Hillstrom R. Effects of a Medial Knee Unloading Implant on Tibiofemoral Joint Mechanics During Walking. J Orthop Res. 2019 May 23. doi: 10.1002/jor.24379.
  • Heard BJ, Barton KI, Agbojo OM, Chung M, Sevick JL, Bader TJ, Martin CR, Shrive NG, Hart DA. Molecular Response of Rabbit Menisci to Surgically Induced Hemarthrosis and a Single Intra-Articular Dexamethasone Treatment. J Orthop Res. 2019 Sep;37(9):2043-2052.
  • Lee DH, D'Lima DD, Lee SH. Clinical and Radiographic Results of Partial Versus Total Meniscectomy in Patients with Symptomatic Discoid Lateral Meniscus: A systematic Review and Meta-Analysis. Orthop Traumatol Surg Res. 2019 Jun;105(4):669-675.
  • Baek J, Lotz MK, D'Lima DD. Core-Shell Nanofibrous Scaffolds for Repair of Meniscus Tears. Tissue Eng Part A. 2019 Aug 14. doi: 10.1089/ten.TEA.2018.0319.
  • Lonza GC, Gardner-Morse MG, Vacek PM, Beynnon BD. Radiographic-Based Measurement of Tibiofemoral Joint Space Width and Magnetic Resonance Imaging Derived Articular Cartilage Thickness are Not Related in Subjects at Risk for Post-Traumatic Arthritis of the Knee. J Orthop Res. 2019 May;37(5):1052-1058.
  • Tarafder S, Gulko J, Kim D, Sim KH, Gutman S, Yang J, Cook JL, Lee CH. Effect of Dose and Release Rate of CTGF and TGFβ3 on Avascular Meniscus Healing. J Orthop Res. 2019 Jul;37(7):1555-1562.
  • Park JY, Kim BH, Ro DH, Lee MC, Han HS. Characteristic Location and Rapid Progression of Medial Femoral Condylar Chondral Lesions Accompanying Medial Meniscus Posterior Root Tear. Knee. 2019 Jun;26(3):673-678.
  • Wilson S, Hausselle J, Guess TM, Gonzalez RV. Rigid-Body Modeling of Knee Cartilage and Meniscus Using Experimental Pressure-Strain Curves. Comput Methods Biomech Biomed Engin. 2019 May;22(6):574-584.
  • Rai MF, Tycksen ED, Cai L, Yu J, Wright RW, Brophy RH. Distinct Degenerative Phenotype of Articular Cartilage from Knees with Meniscus tear Compared to Knees with Osteoarthritis. Osteoarthritis Cartilage. 2019 Jun;27(6):945-955.
  • Hewison C, Kolaczek S, Caterine S, Berardelli R, Beveridge T, Lording T, Akindolire J, Herman B, Hurtig M, Gordon K, Getgood A. Peripheral Fixation of Meniscal Allograft Does Not Reduce 

Names in bold are ORS Meniscus Section members.